CAPRI Clinical Trials
To obtain a protocol or open a trial at your centre, please use the contact information below.
RESPIRE-ILD
Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease (RESPIRE-ILD): A 2x2 Factorial Randomized Phase II Trial testing N-Acetyl Cysteine and Dexamethasone
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Study Question:
Do N-acetylcysteine and/or dexamethasone reduce radiation-related dyspnea in patients with ILD and lung cancer? Principal Investigators: Dr. Houda Bahig Dr. David Palma Target Accrual: 98 patients Current Status: Opened Jan 2025 ClinicalTrials.gov Identifier: NCT05986318 |
REPAIR
A Safety and Efficacy Trial of Reirradiation Dose Escalation in Thoracic Cancers: Re-evaluating previous dose and allowing increasing recovery
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Study Question:
When delivering re-irradiation for lung cancers, how much tissue recovery can we allow? Principal Investigators: Dr. Donna Murrell Dr. David Palma Target Accrual: 48 Current Status: Opening March 2025 ClinicalTrials.gov Identifier: NCT06558175 |
PREVENT
A Phase II Randomized Evaluation of Dose-Escalation with Esophageal-Sparing for Palliation of Intra-thoracic Tumors
Study Question:
When delivering palliative radiation for lung cancer, dose a higher dose of 35 Gy in 5 fractions lead to better QOL and survival than standard palliative doses?
Principal Investigators:
Dr. Chris Goodman
Dr. Alexander Louie
Dr. David Palma
Target Accrual: 150 patients
Current Status: Expected opening late 2025
When delivering palliative radiation for lung cancer, dose a higher dose of 35 Gy in 5 fractions lead to better QOL and survival than standard palliative doses?
Principal Investigators:
Dr. Chris Goodman
Dr. Alexander Louie
Dr. David Palma
Target Accrual: 150 patients
Current Status: Expected opening late 2025
Selection of Trials for CAPRI
Trial proposals are solicited from investigators across Canada. All trials are peer-reviewed in a double-blind process by both Canadian and International experts. Proposals are scored based on novelty, scientific relevance, feasibility, methodology, and potential for clinical impact. If you are an investigator wishing to propose a trial, please contact us below.
Funding of CAPRI Trials
CAPRI trials are funded through philanthropic donations made to the London Health Sciences Foundation, and operating research funds from the Ontario Institute for Cancer Research.